ISPPP 2019 Scientific Program – click here
The ISPPP Conference Committee invites you to join scientists from around the world who will deliver some of the most cutting-edge presentations on the separation, purification, and characterization of biologically important molecules, much of which is based on HPLC/UHPLC/Mass Spectrometry. The Symposium will provide opportunities to present and discuss key developments and applications, productivity and financial challenges, and novel approaches related to biological molecule separations and analysis focusing on the latest innovations in technologies that are critical in clinical and biopharmaceutical research, and are requirements in the manufacturing and quality control of new biotherapies and diagnostics. It’s an exciting time for the separation science of biological molecules. The field continues to grow and adapt, enjoy better materials, instruments and methods, and a seeming never-ending list of interesting molecules to work on. Vendor Exhibits. The Exhibit will provide access to the latest advances in media, equipment, and services. The program will ensure ample opportunities to meet commercial suppliers featuring state-of-the-art instrumentation, equipment, stationary phases, columns, etc. in an integrated lecture, poster, and booth display area within the facility. Exhibitors will also have an opportunity to present workshops.
ISPPP 2024 Preliminary Program
Bionanoparticles – Session Chair – Alois Jungbauer
Alois Jungbauer, Professor, Institute of Bioprocess Science and Engineering, Department of
Biotechnology, BOKU University
Title of Talk – TBA
Soheyl Tadjiki, Managing Director, Postnova Analytics
Characterization of drug delivery vectors using Field-Flow Fractionation coupled with
Light Scattering
Alexei Voloshin, Global Head Bioprocess Science, Solventum
Novel Technologies for Large Particle Separations and Control in Bioprocessing
Fundamentals of Separations – Session Chair – Mark Schure
Mark Schure, Chief Technology Officer, Kroungold Analytical
Molecular Simulations and Retention Measurements of Hydrophilic Interaction Liquid
Chromatography (HILIC): How HILIC works
Oleg Krokhin, Associate Professor, Internal Medicine, University of Manitoba,
Peptide separation selectivity of reversed-phase C18 separation media for proteomic
applications
Process Technology and Analytics – Session Chair – Todd Maloney (3P)
Plenary Speaker
Todd Maloney, Executive Director in Synthetic Molecule Design and Development, Eli Lilly
Process Analytical Technology for Advanced Process Understanding and Control: Case Studies in
Synthetic Drug Substance Process Development and Manufacturing
Nicholas Skizim, Senior Director, Analytical Sciences, Greenlight Biosciences
A comprehensive approach to the quantification and characterization of double-stranded
RNA (dsRNA) products as a new generation of crop protection agents
Imre Sallay, Product Manager, Osaka Soda
“Is it any good?” Science driven evaluation system of bulk silica phases for large scale
peptide API purification
Ana I. Valente, Aveiro Institute of Materials CICECO – Aveiro Institute of Materials, Department
of Chemistry, Aviero University
Pre-purification of minicircle DNA from cell lysates with ionic liquid-based aqueous
biphasic systems
Quality by design (process, purification & analytical) – Session Chair – Emily Schirmer
Emily Schirmer, General Manager, Catalent Pharma Solutions
Title of Talk – TBA
Jonas Wege, Application Development Manager, Tosoh Bioscience GmbH
Step Gradient Simulated Moving Bed Purification Process for Anion Exchange
Chromatography
Matthew Dalphin, Senior Scientist, Analytical Development, Catalent Pharma Solutions
Analytical Quality by Design and its Role in Accelerating the Process Development and
Biomanufacturing of Monoclonal Antibodies
Brian Domanski, Strategic Collaboration Scientist – Pharma/Biopharma, Shimadzu Scientific
Instruments, Inc.
Development and Optimization of SFC Polypeptide Separations Using Automation and
QbD Principles Newer Therapeutic Modalities – Session Chair – James Martosella
James Martosella, GSK, GSK Associate Fellow, Associate Director,
Critical Late-Stage Ion Pairing Reversed-Phase Liquid Chromatography (IP-RPLC)
Method Optimizations for a siRNA Oligonucleotide Release Assay
Binchuan Wei, Senior Principal Scientist, Synthetic Molecule Chemistry, Genentech
Characterization of guide RNA for CRISPR: Methods, Mechanisms and Applications
Wei-Chiang Chen, Associate Director, BioProcess Analytics, Genomic Medicine Unit,
Sanofi
An LC-based, Multi-attribute Method Supporting the Process Development for Non-viral
Gene Therapy
Advancing Approaches for Biomolecule Analysis – Session Chair – Brian Wei, Sanofi
Ashli Simone, Technical Market Manager, MOBILionSystems
Nanoflow Need Not Apply- Analytical Flow HRIM-MS Works to Resolve Native Protein-
Ligand Binding
Imre Molnár, Principal, Molnar-institute
Unveiling Column Interchangeability in UHPLC through Multivariate Modeling: A Case
Study
Hoang Kim Ngan Thai, CCRC, University of Georgia
How Complementary are HILIC, Ion Mobility, and MS for The Analysis of N-glycan
Isomers?
Oluwatosin Daramola, Dept. Biochemistry and Chemistry, Texas Tech University
Targeted Metabolite Analysis Using LC-MS/MS with Parallel Reaction Monitoring (PRM)
Glycomics/glycoproteomics – Session Chair – Yehia Mechref
Yehia Mechref, Robert A. Welch Endowed Chair in Chemistry , Paul W. Horn Distinguished
Professor, Associate Vice President for Research and Innovation. Director, TTU Center for
Biotechnology & Genomics, Texas Tech University,
Title of Talk: TBA
Mya Brown, CCRC, University of Georgia
Identifying the Absolute Stereochemical Configuration of Biopolymer Building Blocks
with Ion Mobility-Mass Spectrometry
Brian Wei, Senior Scientist, Bioprocess Analytics, Sanofi
High-Throughput Analytical Assay Development for N-Glycans in Novel Protein-Based
Modalities
Sherifdeen Onigbinde, Department of Chemistry and Biochemistry, Texas Tech University,
Defining the Role of Glycosylation in Traumatic Brain Injury: An Innovative Analysis of
IgG Glycosylation
Higher Order Structure Analysis – Session Chair – Ron Orlando (8P)
Plenary Speaker
Michael L. Gross, Professor of Chemistry and of Immunology and Internal Medicine (School of
Medicine), Washington University in St. Louis
Protein Footprinting and Applications for Soluble and Membrane Proteins
Binchuan Wei, Sr. Principal Scientist, Genentech
Unveiling Structural-Function Relationship through Hydrogen Deuterium Exchange Coupled
with Mass Spectrometry (HDX-MS)
Kyle Anderson, Project Leader, HDX-MS for Biopharmaceutical Analysis
National Institute of Standards and Technology
Title of Talk: TBA
Nucleic Acid Separations – Session Chair – Bingchuan Wei
Barry Boyes, Chief Technology Officer, Advanced Materials Technologies, Inc.
Examining Pore Size Effects for Superficially Porous Particles Applied to Ion Pairing-
Reversed Phase Separations of Nucleic Acids
Ana I. Valente, Aveiro Institute of Materials CICECO – Aveiro Institute of Materials, Department
of Chemistry, University of Aveiro
Pre-purification of minicircle DNA from cell lysates with ionic liquid-based aqueous
biphasic systems
Protein Therapeutic Separations – Session Chair – Barry Boyes
Li Cao, Sr. Manager, Strategic External Development, GSK
Advancements in Determination and Characterization of DAR in Antibody Drug
Conjugates
Lance Cadang, Principal Scientist, Genentech
Native HIC MS of ADCs for DAR species determination and identification
Leonor Castro, Aveiro Institute of Materials, University of Aveiro
Exploring the potential of polymeric ionic liquids as chromatographic supports for
Interferon downstream processing
POSTER Session
Yuko Fukuyama, Researcher, Shimadzu Corporation
Simple antisense oligonucleotides analyses using matrix-assisted laser-
desorption/ionization digital-ion-trap mass spectrometry
Flávia Magalhães, Aveiro Institute of Materials, Department of Chemistry, University of Aveiro,
flaviamagalhaes@ua.pt
Enhancing the production of enzymes by designing an extractive fermentation process
Barry Boyes, Chief Technology Officer, Advanced Materials Technologies, Inc.
Charged-Surface Reversed-Phase Superficially Porous Particles for Analysis of
Biomolecules
Inês Santana, University of Aveiro
Ionic liquid and sodium salt-based aqueous biphasic systems for the enhanced
quantification of bisphenol A in human serum
Ana Filipa Pereira, University of Aveiro
Effective separation of nucleic acids from complex bacterial lysates using three-phase
partitioning systems based on biocompatible ionic liquids
Erin Demko, W. L. Gore & Associates, Development Engineer, edemko@wlgore.com
Building a Fully Single-Use Process: High Productivity Protein A Membrane Devices that
Complement Disposable Upstream Technology